Room 804B, 17 Lex., Phone: (646) 660-6220, E-mail:
M. Hoffman, Ph.D., New York University (Organic Chemistry), has
conducted research related to biochemical studies of enzymes and
glycosphingolipids in Tay-Sachs disease. Her work on enzyme replacement
experiments to "cure" Tay-Sachs disease in cell culture resulted
in the Moore Award of the American Society of Neuropathologists
in 1980. More recently she has been using her expertise on glycolipids
to look for changes in glycolipids in the membranes of cancer
cells derived from brain tumors as compared to normal cells. Her
publications have appeared in journals and books on neuroscience.
Dr. Hoffman has advised honors and independent study students.
by many investigators during the last 20 years in the field of Tay-Sachs
disease has resulted in eliminating 90% of diagnosed cases of the disease
by the use of genetic screening and fetal diagnosis (amniocentesis).
I have worked with cell culture systems to learn more about the disease.
The first paper, listed below, is an attempt, in collaboration with
Canadian workers, to "cure" Tay-Sachs disease in laboratory cell culture.
The second paper deals with another aspect of my current research, that
is, the examination of membrane components on cancer cells as compared
to normal cells."
M. J., D. Leclerc, R. Gravel, L. M. Hoffman, S. E. Brooks, P. Hechtman,
and F. Kaplan. 1994.
Hex A expression in a transformed human fetal Tay-Sachs disease
neuroglial cell line. Proc. Amer. Soc. Human Genetics 55:
L. M., S. E. Brooks, M. R. Stein, and L. Schneck. 1994.
causes differentiation and decreases the expression of neutral glycosphingolipids
in cell cultures derived from a malignant glioma. Biochim. Biophys.
Acta, 1222: 37-44.