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Office:
Room 506B, 17 Lex., Phone: (646) 660-6252, E-mail:
MaryJean_Holland@baruch.cuny.edu
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Mary
Jean Holland, Ph.D., New York University (Biology), is a biochemist
whose research is concerned with the role of molecules in cell
membranes and within cell cytoplasm in metabolism and in drug
therapy. She has collaborated with neurobiologists at the New
York University Medical Center and chemists at Brookhaven National
Laboratory in work supported by the National Institutes of Health;
results have been published in pharmacological and physiological
journals.
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Professor
Holland is especially concerned with science teaching at Baruch College.
As course coordinator of BIO 1003, she has modified the syllabus to
emphasize ecological knowledge; she has worked with advanced students
to develop a new laboratory component in which students design experiments
themselves, carry them out, and present oral reports to the class and
a written paper. She is Principal Investigator on a current National
Science Foundation Grant entitled "Communicating Science:Science Learning
Through Science Writing." She has served as Chair of the School of Liberal
Arts and Sciences Curriculum Committee and is an active member of the
University-wide Committee on Writing in the Disciplines.
RESEARCH
"My
research career spans more than 25 years. The most significant research
includes:
- studying
infectious drug resistance at Merck & Co. (1968, Am. J. Vet.
Res., 29: 1067-1072);
- using
intact cells rather than cell extracts to measure enzyme activity
in patients with a genetic disease (1976, J. Clin. Invest.,
57: 1600-1605);
- demonstrating
the transport mechanism for hypoxanthine in human cells (1978, Exper.
Cell Res., 108: 461-464);
- modeling
of adenosine metabolism in intact human cells (1985, Am. J. Physiol.
(Cell), 248: 21-26);
- determining
the pharmacokinetics of a narcotic analagesic, buprenorphine (1989,
Res. Commun. Chem. Path. Pharmacol., 64: 3-16);
- imaging
of opioid receptors in primate brain (1990, Nucl. Med. Biol.,
17: 217-227; 1991, Nucl. Med. Biol., 18: 281-288);
- developing
mathematical models for drug-receptor interaction (1990, New Leads
in Opioid Research; 1994, Modeling and Control in Biological Systems<).
Future
directions include examining the potential for bioremediation of environmental
damage by using soil microorganisms to degrade pollutants."
Publications
1992-Present
| Holland,
M. J. 1994. |
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Kinetic
model for drug distribution and binding in brain. Pp. 269-270, in
B. W. Paterson, ed., Modeling and Control in Biomedical Systems,.
Omnipress, Madison, WI. |
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