Mary Jean Holland

General Biology and Microbiology

Phone: (646) 660-6252
Location: Rm 506B, 17 Lexington Ave

Mary Jean Holland, Ph.D., New York University (Biology), is a biochemist whose research is concerned with the role of molecules in cell membranes and within cell cytoplasm in metabolism and in drug therapy. She has collaborated with neurobiologists at the New York University Medical Center and chemists at Brookhaven National Laboratory in work supported by the National Institutes of Health; results have been published in pharmacological and physiological journals.

Professor Holland is especially concerned with science teaching at Baruch College. As course coordinator of BIO 1003, she has modified the syllabus to emphasize ecological knowledge; she has worked with advanced students to develop a new laboratory component in which students design experiments themselves, carry them out, and present oral reports to the class and a written paper. She is Principal Investigator on a current National Science Foundation Grant entitled "Communicating Science:Science Learning Through Science Writing." She has served as Chair of the School of Liberal Arts and Sciences Curriculum Committee and is an active member of the University-wide Committee on Writing in the Disciplines.


"My research career spans more than 25 years. The most significant research includes:

1. studying infectious drug resistance at Merck & Co. (1968, Am. J. Vet. Res., 29: 1067-1072);
2. using intact cells rather than cell extracts to measure enzyme activity in patients with a genetic disease (1976, J. Clin. Invest., 57: 1600-1605);
3. demonstrating the transport mechanism for hypoxanthine in human cells (1978, Exper. Cell Res., 108: 461-464);
4. modeling of adenosine metabolism in intact human cells (1985, Am. J. Physiol. (Cell), 248: 21-26);
5. determining the pharmacokinetics of a narcotic analagesic, buprenorphine (1989, Res. Commun. Chem. Path. Pharmacol., 64: 3-16);
6. imaging of opioid receptors in primate brain (1990, Nucl. Med. Biol., 17: 217-227; 1991, Nucl. Med. Biol., 18: 281-288);
7. developing mathematical models for drug-receptor interaction (1990, New Leads in Opioid Research; 1994, Modeling and Control in Biological Systems<).

Future directions include examining the potential for bioremediation of environmental damage by using soil microorganisms to degrade pollutants."


Holland, M. J. 1994.

          Kinetic model for drug distribution and binding in brain. Pp. 269-270, in B. W. Paterson, ed., Modeling and Control in Biomedical Systems,. Omnipress, Madison, WI.

The City University of New York