Jean P. Gaffney

Assistant Professor of Chemistry

Email: jean.gaffney@baruch.cuny.edu
Phone: 646-660-6229
Location: Rm 506, 17 Lexington Avenue

Biography

Jean Gaffney completed her undergraduate degree in chemistry at Binghamton University (SUNY). She attended Yale University for her Ph.D. with Ann M. Valentine, where she studied the metal binding properties of a novel monolobal transferrin from the ascidian Ciona intestinalis. Following her doctoral work, she completed a postdoctoral fellowship at the Weizmann Institute of Science with Irit Sagi, where she focused on understanding a class of enzymes implicated in cancer known as the matrix metalloproteinases. She joined the Baruch faculty as an assistant professor in the fall of 2014.

Research Interests

Dr. Gaffney is interested in continuing to understand the role of the matrix metalloproteinases (MMPs) in diseases such as cancer. The MMPs have been implicated in homeostatic roles as well as in disease states, which makes them a challenging yet critical target for therapeutics.


Selected Publications:

J. Gaffney, I. Solomonov, E. Zehorai, I. Sagi. Multilevel Regulation of Matrix Metalloproteinases in Tissue Homeostasis Indicates Their Molecular Specificity In-Vivo. Matrix Biology. Accepted for publication on January 18, 2015.

F. Amos, K. Cole, R.L. Meserole, J.P. Gaffney, and A.M. Valentine. Titanium mineralization in ferritin: A room temperature non-photochemical preparation and biophysical characterization. Journal of Biological Inorganic Chemistry 2013; 18(3): 145-152.

J.P. Gaffney and A.M. Valentine. Beyond Bilobal: Transferrin homologs having unusual domain architecture. Biochimica et Biophysica Acta- General Subjects 2012; 1860(3): 212-217.

J.P. Gaffney and A.M. Valentine. The challenges of trafficking hydrolysis prone metals and ascidians as an archetype. Dalton Transactions 2011; 40(22): 5287-5385.

J.P Gaffney and A.M. Valentine. Contrasting synergistic anion effects in vanadium(V) binding to nicatransferrin versus human serum transferrin. Biochemistry 2009; 48(49): 11609-11611.

D.M. Sarno, J.J. Martin, S.M. Hira, C.J Timpson, J.P Gaffney and W.E. Jones. Enhanced conductivity of thin film polyaninline by self-assembled transition metal complexes. Langmuir 2007; 23(2): 879-884


The City University of New York